Assuntos
Humanos , Criança , Otite Média/tratamento farmacológico , Penicilinas/farmacologia , Sinusite/tratamento farmacológico , Faringite/tratamento farmacológico , Penicilinas/efeitos adversos , Penicilinas/farmacocinética , Macrolídeos/efeitos adversos , Macrolídeos/farmacologia , Macrolídeos/farmacocinéticaRESUMO
Three cases of meningitis due to criptococcus in children infected with HIV are reported. All patients had severe immunodeficiency. The first case occurred before antiretroviral therapy. The second case had poor adherence to treatment. The third case is a teenager with prolonged fever, who did not have a clear source of transmission of HIV and was immunodeficient at the time of diagnosis. Examination of cerebrospinal fluid with India ink dye was essential for making the diagnosis in all three cases. The disease course was adequate in all three patients despite flucytosine not being available.
Se presentan tres casos de meningitis por Cryptococcus sp. en niños infectados con VIH e inmunodeficiencia grave. El primero fue en la época en que no se disponía de TAR. El segundo fue un paciente no adherente al tratamiento. La tercera fue una adolescente en la que se hizo diagnóstico por una enfermedad febril prolongada, donde no fue posible encontrar la fuente de transmisión de VIH y que en el momento del diagnóstico estaba con inmunosupresión grave. En los tres fue fundamental para el diagnóstico rápido la tinción de LCR con tinta china. La evolución de la enfermedad fue adecuada en los tres pacientes aunque no se contó en ninguno de los casos con flucitosina.
Assuntos
Adolescente , Criança , Feminino , Humanos , Masculino , Infecções Oportunistas Relacionadas com a AIDS/diagnóstico , Cryptococcus neoformans , Meningite Criptocócica/diagnóstico , Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico , Meningite Criptocócica/tratamento farmacológicoRESUMO
Three cases of meningitis due to criptococcus in children infected with HIV are reported. All patients had severe immunodeficiency. The first case occurred before antiretroviral therapy. The second case had poor adherence to treatment. The third case is a teenager with prolonged fever, who did not have a clear source of transmission of HIV and was immunodeficient at the time of diagnosis. Examination of cerebrospinal fluid with India ink dye was essential for making the diagnosis in all three cases. The disease course was adequate in all three patients despite flucytosine not being available.
